Polycystin-2 is an intracellular calcium release channel.

  title={Polycystin-2 is an intracellular calcium release channel.},
  author={Peter Koulen and Yiqiang Cai and Lin Geng and Yoshiko Maeda and Sayoko Nishimura and Ralph Witzgall and Barbara E Ehrlich and Stefan Somlo},
  journal={Nature cell biology},
  volume={4 3},
Polycystin-2, the product of the gene mutated in type 2 autosomal dominant polycystic kidney disease (ADPKD), is the prototypical member of a subfamily of the transient receptor potential (TRP) channel superfamily, which is expressed abundantly in the endoplasmic reticulum (ER) membrane. Here, we show by single channel studies that polycystin-2 behaves as a calcium-activated, high conductance ER channel that is permeable to divalent cations. Epithelial cells overexpressing polycystin-2 show… CONTINUE READING
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