Polycystin 2 interacts with type I inositol 1,4,5-trisphosphate receptor to modulate intracellular Ca2+ signaling.

@article{Li2005Polycystin2I,
  title={Polycystin 2 interacts with type I inositol 1,4,5-trisphosphate receptor to modulate intracellular Ca2+ signaling.},
  author={Yun Li and Jerry Mobley Wright and Feng Qian and Gregory G Germino and William B Guggino},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 50},
  pages={
          41298-306
        }
}
Autosomal dominant polycystic kidney disease, a common cause of renal failure, arises from mutations in either the PKD1 or the PKD2 gene. The precise function of both PKD gene products polycystins (PCs) 1 and 2 remain controversial. PC2 has been localized to numerous cellular compartments, including the endoplasmic reticulum, plasma membrane, and cilia. It is unclear what pools are the most relevant to its physiological function as a putative Ca2+ channel. We employed a Xenopus oocyte Ca2… CONTINUE READING
Highly Cited
This paper has 68 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 59 citations

68 Citations

05'08'11'14'17
Citations per Year
Semantic Scholar estimates that this publication has 68 citations based on the available data.

See our FAQ for additional information.