Polycystin-2 cation channel function is under the control of microtubular structures in primary cilia of renal epithelial cells.

@article{Li2006Polycystin2CC,
  title={Polycystin-2 cation channel function is under the control of microtubular structures in primary cilia of renal epithelial cells.},
  author={Qiang Li and Nicol{\'a}s Montalbetti and Yuliang Wu and Arnolt Ramos and Malay K. Raychowdhury and X. Chen and Horacio F Cantiello},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 49},
  pages={37566-75}
}
Mutations in the gene encoding polycystin-2 (PC2) result in autosomal dominant polycystic kidney disease and defects in left-right asymmetry during embryogenesis. PC2 is a TRP-type Ca(2+)-permeable non-selective cation channel, which is expressed in kidney and other organs. PC2 is present and functional in microtubule-containing primary cilia of renal epithelial cells. However, no information is yet available as to whether PC2 interacts with microtubules. Here, we assessed the role of… CONTINUE READING

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