Polycystin-2 and phosphodiesterase 4C are components of a ciliary A-kinase anchoring protein complex that is disrupted in cystic kidney diseases.

@article{Choi2011Polycystin2AP,
  title={Polycystin-2 and phosphodiesterase 4C are components of a ciliary A-kinase anchoring protein complex that is disrupted in cystic kidney diseases.},
  author={Yun-Hee Choi and Akira Suzuki and Sachin S Hajarnis and Zhendong Ma and Hannah C. Chapin and Michael J Caplan and Marco Pontoglio and Stefan Somlo and Peter Igarashi},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 26},
  pages={10679-84}
}
Polycystic kidney disease (PKD) is a genetic disorder that is characterized by cyst formation in kidney tubules. PKD arises from abnormalities of the primary cilium, a sensory organelle located on the cell surface. Here, we show that the primary cilium of renal epithelial cells contains a protein complex comprising adenylyl cyclase 5/6 (AC5/6), A-kinase anchoring protein 150 (AKAP150), and protein kinase A. Loss of primary cilia caused by deletion of Kif3a results in activation of AC5 and… CONTINUE READING
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