Polycystin-1 activates the calcineurin/NFAT (nuclear factor of activated T-cells) signaling pathway.

@article{Puri2004Polycystin1AT,
  title={Polycystin-1 activates the calcineurin/NFAT (nuclear factor of activated T-cells) signaling pathway.},
  author={Sanjeev Puri and Brenda S. Magenheimer and Robin L. Maser and Erin M Ryan and Christopher A Zien and Danielle D. Walker and Darren P Wallace and Scott J. Hempson and James P. Calvet},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 53},
  pages={55455-64}
}
Regulation of intracellular Ca(2+) mobilization has been associated with the functions of polycystin-1 (PC1) and polycystin-2 (PC2), the protein products of the PKD1 and PKD2 genes. We have now demonstrated that PC1 can activate the calcineurin/NFAT (nuclear factor of activated T-cells) signaling pathway through Galpha(q) -mediated activation of phospholipase C (PLC). Transient transfection of HEK293T cells with an NFAT promoter-luciferase reporter demonstrated that membrane-targeted PC1… CONTINUE READING
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