Polycystic ovary syndrome.

@article{Franks1997PolycysticOS,
  title={Polycystic ovary syndrome.},
  author={Stephen Franks},
  journal={Archives of disease in childhood},
  year={1997},
  volume={77 1},
  pages={
          89-90
        }
}
  • S. Franks
  • Published 28 September 1995
  • Medicine, Biology
  • Archives of disease in childhood
Polycystic ovary syndrome (PCOS) is the commonest endocrine disorder in women of reproductive age. The classical symptoms are those of hyperandrogenism (hirsutism, persistant acne, androgen dependent alopecia) together with symptoms of anovulation (infertility, amenorrhoea, irregular dysfunctional uterine bleeding). In the last 10 to 15 years, the use of high resolution pelvic ultrasonography has greatly facilitated identification of polycystic ovaries in women with hirsutism or menstrual… 
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References

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Prevalence of polycystic ovaries in women with anovulation and idiopathic hirsutism.
TLDR
It is shown that polycystic ovaries, as defined by pelvic ultrasound, are very common in anovulatory women and are not necessarily associated with hirsutism or a raised serum luteinising hormone concentration.
Ovulatory disorders in women with polycystic ovary syndrome.
TLDR
Of the medical methods of ovulation induction in clomiphene non-responders, two methods have emerged as being highly promising: the first is administration of HMG following suppression of the pituitary by an LH-RH analogue and the second is low-dose FSH.
Epidemiology of infertility and polycystic ovarian disease: endocrinological and demographic studies.
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  • Medicine, Biology
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
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TLDR
The results show that by contrast with the groups having hyperprolactinemia or hypothalamic disorder the group with hirsutism (and therefore presumed PCOD) was closely resembled by a non-hirsute group in terms of estrogenization, LH level, LH/FSH ratio, prolactin level, body mass and responsiveness to clomiphene.
Insulin resistance in polycystic ovary syndrome.
Hyperprolactinemia in polycystic ovary syndrome.
Detection of functional ovarian hyperandrogenism in women with androgen excess.
TLDR
Almost half of women with oligomenorrhea, hirsutism, or acne have an abnormal response to the gonadotropin-releasing hormone agonist nafarelin, suggesting an ovarian cause of their androgen excess.
HETEROGENEITY OF THE POLYCYSTIC OVARY SYNDROME: CLINICAL, ENDOCRINE AND ULTRASOUND FEATURES IN 556 PATIENTS
TLDR
This paper reports an analysis of the clinical, endocrine and ultrasound data within a population of 556 patients with ultrasound‐diagnosed polycystic ovaries to illustrate the limitations in the use of specific clinical or endocrine criteria as requirements for the diagnosis of the poly Cystic ovary syndrome.
FAMILIAL POLYCYSTIC OVARIES: A GENETIC DISEASE?
TLDR
The observed segregation ratios were significantly different from those predicted for autosomal dominant and X‐linked dominant modes of inheritance and environmental factors, such as the effect of maternal androgen on gonadal develpment, are considered.
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