Polycystic ovary syndrome is associated with genetic polymorphism in the insulin signaling gene IRS-1 but not ENPP1 in a Japanese population.

@article{Baba2007PolycysticOS,
  title={Polycystic ovary syndrome is associated with genetic polymorphism in the insulin signaling gene IRS-1 but not ENPP1 in a Japanese population.},
  author={Tsuyoshi Baba and Toshiaki Endo and Fumihiro Sata and Hiroyuki Honnma and Yoshimitsu Kitajima and Takuhiro Hayashi and Kengo Manase and Mika Kanaya and Hideto Yamada and Hisanori Minakami and Reiko Kishi and Tsuyoshi Saito},
  journal={Life sciences},
  year={2007},
  volume={81 10},
  pages={850-4}
}
Recent studies indicate that insulin resistance resulting from altered post-receptor signaling is associated with polycystic ovary syndrome (PCOS). We hypothesized that insulin receptor substrate-1 (IRS-1) Gly972Arg polymorphism and/or ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) Lys121Gln polymorphism predisposes women to PCOS and that these polymorphisms also affect anthropometric variables, glucose metabolism and androgen synthesis. To test those ideas, we studied the genotypes… CONTINUE READING

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