Polycystic ovary syndrome in women using valproate: A review

@article{Bilo2008PolycysticOS,
  title={Polycystic ovary syndrome in women using valproate: A review},
  author={Leonilda Bilo and Roberta Meo},
  journal={Gynecological Endocrinology},
  year={2008},
  volume={24},
  pages={562 - 570}
}
  • L. Bilo, R. Meo
  • Published 1 January 2008
  • Medicine
  • Gynecological Endocrinology
Valproate (VPA) is a highly effective drug successfully employed in several neuropsychiatric diseases. In the last 15 years, an increased prevalence of polycystic ovary syndrome (PCOS) associated with VPA use has been reported in both women with epilepsy and women with bipolar disorders. However, data on this subject are contrasting and it is possible that different factors might play a role in the development of PCOS in these patients. The risk of developing PCOS during VPA treatment seems to… 
Valproate-Induced Polycystic Ovary Syndrome in a Girl with Epilepsy: A Case Study.
TLDR
The risk of PCOS developing in patients with epilepsy is known to be high, and the association of VPA with PCOS is well established, so physicians should carefully monitor the patients' weight and menstruation, and immediately perform ovarian imaging and hormonal examinations if any abnormalities are observed.
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TLDR
If accepted, these concepts could help clinicians to perform in-depth investigations of the potential factors or disorders responsible for the development of these specific forms of secondary PCOS and contribute to develop further research on factors and mechanisms involved in theDevelopment of the classic and the nonclassic PCOS phenotypes.
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TLDR
The higher prevalence of psychiatric disorders in patients with PCOS, especially depression and anxiety disorders, may be due to both hyperandrogenism and the resulting somatic symptoms.
MANAGEMENT OF ENDOCRINE DISEASE: Secondary polycystic ovary syndrome: theoretical and practical aspects.
TLDR
If accepted, these concepts could help clinicians to perform in-depth investigations of the potential factors or disorders responsible for the development of these specific forms of secondary PCOS and contribute to develop further research on factors and mechanisms involved in theDevelopment of the classic and the nonclassic PCOS phenotypes.
Neuroendocrine Impairments of Polycystic Ovary Syndrome
TLDR
An overview of what is known about alterations in the steroid hormone-sensitive GnRH neuronal network that may underlie the neuroendocrine defects in clinical PCOS is provided, with a particular focus on those that may contribute to impaired progesterone negative feedback, and the likely role of androgens in driving this impairment.
Polycystic Ovary Syndrome (PCOS) and Sexual Dysfunctions
TLDR
Focus on sexual dysfunctions in PCOS has been emphasized only recently after high rates of its prevalence have been found and proper assessment and management of sexual Dysfunctions should be given its due importance.
Endocrine effects of valproic acid therapy in girls with epilepsy: a prospective study.
Risk of Psychiatric Disorders following Polycystic Ovary Syndrome: A Nationwide Population-Based Cohort Study
TLDR
PCOS might increase the risk of subsequent newly diagnosed depressive disorder, anxiety disorder, and sleep disorder, which has often been reported in the literature to be comorbid with PCOS.
Pathological pulses in PCOS
TLDR
This mini-review will briefly describe the pathology of PCOS associated with high frequency GnRH/LH pulses and then highlight what is currently known, and yet to be discovered, about the central mechanisms involved.
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