Polycystic ovary syndrome and endometrial carcinoma

@article{Hardiman2003PolycysticOS,
  title={Polycystic ovary syndrome and endometrial carcinoma},
  author={Paul J Hardiman and Ouma S Pillay and William U Atiomo},
  journal={The Lancet},
  year={2003},
  volume={361},
  pages={1810-1812}
}
CONTEXT An association between polycystic ovary syndrome (PCOS)and endometrial carcinoma was first suggested in 1949, 14 years after the original description of the syndrome. Since then several studies have been published that seem to support this association. The prescription of hormonal treatment to reduce the risk of this complication is supported by the Guidelines for Good Clinical Practice of the Royal College of Obstetricians and Gynaecologists, UK, the Health Information website of the… Expand
Polycystic ovary syndrome and the risk of gynaecological cancer: a systematic review.
TLDR
A meta-analysis of the data suggests that women with PCOS appear to be three times more likely to develop endometrial cancer but are not at increased risk of breast cancer, and there is insufficient evidence to implicate PCOS in the development of vaginal, vulval, cervical or ovarian cancers. Expand
Polycystic ovary syndrome and gynecological cancers: Is there a link?
TLDR
Data available in the literature do not allow a meta-analysis to be carried out to calculate an estimate of the relative risk of endometrial cancer in women with PCOS, and similarly the few available data appear to exclude a strong association between PCOS and breast cancer. Expand
The association between polycystic ovaries and endometrial cancer.
TLDR
The tendency for cyclin D1-expressing endometrial tumours to be more prevalent in Women with PCO challenges the assumption that EC prognosis is improved in women with PCOS. Expand
Polycystic ovary syndrome (PCOS): metformin.
TLDR
A systematic review aims to answer the following clinical question: What are the effects of metformin on hirsutism and menstrual frequency in women with PCOS and presents information relating to the effectiveness and safety of the following interventions. Expand
Reproductive and Obstetrical Consequences of the Polycystic Ovary Syndrome
TLDR
In the long term, women with PCOS have multiple risk factors for the development of endometrial cancer, including centripetal obesity, hyperinsulinemia, diabetes, and chronic anovulation, although the association between PCOS and this cancer is less well established in the epidemiological literature. Expand
The impact of preexisting polycystic ovary syndrome on endometrial cancer recurrence
TLDR
Pre-existing PCOS was a risk factor for recurrence in premenopausal post-operative patients with EC aged 50 years or younger after surgery at this hospital between 2009 and 2013. Expand
Neoplasias associadas à síndrome dos ovários policísticos
TLDR
Few studies have addressed the possibility of a link between PCOS and ovarian cancer and the results are conflicting but suggest that this association is unlikely. Expand
Adolescent polycystic ovary syndrome: pathophysiology and implications of the disease
TLDR
The literature regarding the linkage between obesity, insulin resistance, and hyperinsulinemia in women with PCOS is reviewed and the attempts to standardize the definition and diagnostic criteria for PCOS are discussed. Expand
Chronic Treatment of Polycystic Ovary Syndrome
TLDR
It is in this context that knowledge of the effects of OCP on carbohydrate and lipid metabolism in normal and, particularly, in subjects with PCOS is so critical, given the well-known association of glucose intolerance, dyslipidemia, and cardiovascular events. Expand
Diagnosis and Management of Polycystic Ovary Syndrome
TLDR
Before making the diagnosis of PCOS, other potential etiologies must be excluded, including androgen-secreting ovarian or adrenal tumors and nonclassical congenital adrenal hyperplasia (21-hydroxylase deficiency), hyperprolactinemia, and Cushing’s syndrome. Expand
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References

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Long-term consequences of polycystic ovary syndrome: Results of a 31 year follow-up study
TLDR
Control of obesity is likely to be particularly important for women with a history of PCOS, and mortality and morbidity from coronary heart disease did not differ significantly between the women with PCOS and comparison groups. Expand
The Stein-Leventhal syndrome: analysis of 43 cases with special reference to association with endometrial carcinoma.
This paper reviews the clinical and pathologic features of a group of patients with the Stein-Leventhal syndrome who had been admitted to the Mayo Clinic. The emphasis is on the frequent associationExpand
Mortality of women with polycystic ovary syndrome at long-term follow-up.
TLDR
It is concluded that women with polycystic ovary syndrome do not have markedly higher than average mortality from circulatory disease, even though the condition is strongly associated with diabetes, lipid abnormalities, and other cardiovascular risk factors. Expand
Chronic Anovulation Syndrome and Associated Neoplasia
TLDR
Chronic anovulation syndrome, a spontaneous biologic experiment of unopposed secretion of estrogen by the ovaries, was identified in a cohort of 1270 patients, and the risk of these patients having neoplasia was studied. Expand
Polycystic ovary syndrome.
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TLDR
PCOS can impact women’s reproductive health, leading to anovulatory infertility and higher rate of early pregnancy loss, and the risks of diabetes, cardiovascular disease, hypertension, metabolic syndrome, and endometrial cancer among PCOS patients are significantly increased. Expand
Adenocarcinoma of the endometrium in women 40 years of age or younger.
TLDR
awareness of risk factors in young women who develop endometrial adenocarcinoma leads to earlier diagnosis and will preserve the historically excellent survival rate of young women. Expand
Endometrial adenocarcinoma and the Stein-Leventhal syndrome.
TLDR
Six cases of adenocarcinoma of the endometrium associated with the Stein-Leventhal syndrome are presented and it is suggested that these patients be treated as are any other patients with endometrial cancer. Expand
Increased expression of LH/hCG receptors in endometrial hyperplasia and carcinoma in anovulatory women.
TLDR
The findings suggest that the increased expression of LH/hCG receptors is a feature of endometrial hyperplasia and carcinoma developing in younger anovulatory women including those with PCO. Expand
Histologic study of ovaries from young women with endometrial adenocarcinoma.
TLDR
From a histologic point of view ovaries of patients less than 40 years old who have endometrial adenocarcinoma are more similar to normal ovaries than to polycystic ovaries. Expand
Endometrial carcinoma; ovarian dysfunction--a risk factor in young women.
TLDR
The findings indicate that untreated ovarian dysfunction like that present in polycystic ovarian disease (PCO) with unopposed estrogen action on the endometrium is associated with EC in younger women, and that smoking may protect against EC by an 'anti-estrogenic' effect. Expand
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