Polycystic ovary syndrome and endometrial carcinoma

@article{Hardiman2003PolycysticOS,
  title={Polycystic ovary syndrome and endometrial carcinoma},
  author={Paul J Hardiman and Ouma S Pillay and William Atiomo},
  journal={The Lancet},
  year={2003},
  volume={361},
  pages={1810-1812}
}

Polycystic ovary syndrome (PCOS): metformin.

TLDR
A systematic review aims to answer the following clinical question: What are the effects of metformin on hirsutism and menstrual frequency in women with PCOS and presents information relating to the effectiveness and safety of the following interventions.

Reproductive and Obstetrical Consequences of the Polycystic Ovary Syndrome

TLDR
In the long term, women with PCOS have multiple risk factors for the development of endometrial cancer, including centripetal obesity, hyperinsulinemia, diabetes, and chronic anovulation, although the association between PCOS and this cancer is less well established in the epidemiological literature.

The impact of preexisting polycystic ovary syndrome on endometrial cancer recurrence

TLDR
Pre-existing PCOS was a risk factor for recurrence in premenopausal post-operative patients with EC aged 50 years or younger after surgery at this hospital between 2009 and 2013.

Neoplasias associadas à síndrome dos ovários policísticos

TLDR
Few studies have addressed the possibility of a link between PCOS and ovarian cancer and the results are conflicting but suggest that this association is unlikely.

Adolescent polycystic ovary syndrome: pathophysiology and implications of the disease

TLDR
The literature regarding the linkage between obesity, insulin resistance, and hyperinsulinemia in women with PCOS is reviewed and the attempts to standardize the definition and diagnostic criteria for PCOS are discussed.

Chronic Treatment of Polycystic Ovary Syndrome

TLDR
It is in this context that knowledge of the effects of OCP on carbohydrate and lipid metabolism in normal and, particularly, in subjects with PCOS is so critical, given the well-known association of glucose intolerance, dyslipidemia, and cardiovascular events.

Diagnosis and Management of Polycystic Ovary Syndrome

TLDR
Before making the diagnosis of PCOS, other potential etiologies must be excluded, including androgen-secreting ovarian or adrenal tumors and nonclassical congenital adrenal hyperplasia (21-hydroxylase deficiency), hyperprolactinemia, and Cushing’s syndrome.

Evaluating the association between endometrial cancer and polycystic ovary syndrome.

TLDR
This study has shown that women with PCOS are more likely at increased risk of endometrial cancer, and more studies are required to clarify the exact molecular mechanisms, determine the best way of screening and preventing disease progression.

Polycystic ovary syndrome and risk of endometrial, ovarian, and breast cancer: a systematic review

TLDR
The associations between PCOS and endometrial, ovarian, and breast cancer are complex, with the need to consider many methodological issues in future analyses, and larger well-designed studies, or pooled analyses, may help clarify these complex associations.
...

References

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Long-term consequences of polycystic ovary syndrome: Results of a 31 year follow-up study

TLDR
Control of obesity is likely to be particularly important for women with a history of PCOS, and mortality and morbidity from coronary heart disease did not differ significantly between the women with PCOS and comparison groups.

The Stein-Leventhal syndrome: analysis of 43 cases with special reference to association with endometrial carcinoma.

This paper reviews the clinical and pathologic features of a group of patients with the Stein-Leventhal syndrome who had been admitted to the Mayo Clinic. The emphasis is on the frequent association

Chronic Anovulation Syndrome and Associated Neoplasia

TLDR
Chronic anovulation syndrome, a spontaneous biologic experiment of unopposed secretion of estrogen by the ovaries, was identified in a cohort of 1270 patients, and the risk of these patients having neoplasia was studied.

Polycystic ovary syndrome.

  • A. Dunaif
  • Medicine, Biology
    Current therapy in endocrinology and metabolism
  • 1994
TLDR
PCOS can impact women’s reproductive health, leading to anovulatory infertility and higher rate of early pregnancy loss, and the risks of diabetes, cardiovascular disease, hypertension, metabolic syndrome, and endometrial cancer among PCOS patients are significantly increased.

Endometrial adenocarcinoma and the Stein-Leventhal syndrome.

TLDR
Six cases of adenocarcinoma of the endometrium associated with the Stein-Leventhal syndrome are presented and it is suggested that these patients be treated as are any other patients with endometrial cancer.

Increased expression of LH/hCG receptors in endometrial hyperplasia and carcinoma in anovulatory women.

TLDR
The findings suggest that the increased expression of LH/hCG receptors is a feature of endometrial hyperplasia and carcinoma developing in younger anovulatory women including those with PCO.

Histologic study of ovaries from young women with endometrial adenocarcinoma.

TLDR
From a histologic point of view ovaries of patients less than 40 years old who have endometrial adenocarcinoma are more similar to normal ovaries than to polycystic ovaries.

Endometrial carcinoma; ovarian dysfunction--a risk factor in young women.

Endometrial hyperplasia and the risk of endometrial carcinoma.

TLDR
Polycystic Ovary Disease and subfertility were found significantly in the cases with cytological atypia; however, they were not significant in the Cases with carcinoma.