Polycystic ovary syndrome: the influence of environmental and genetic factors.

  title={Polycystic ovary syndrome: the influence of environmental and genetic factors.},
  author={Evanthia Diamanti-Kandarakis and Christina Piperi and Jiovanna Spina and Georgia Argyrakopoulou and Lambrini Papanastasiou and Angeliki Bergiele and Dimitrios K Panidis},
  volume={5 1},
Polycystic ovary syndrome (PCOS) is a complex and heterogeneous disorder characterized by hyperandrogenemia, hyperinsulinemia, insulin resistance, and chronic anovulation. It is the most common endocrine disorder in women of reproductive age with an enigmatic pathophysiologic and molecular basis. The high prevalence of affected individuals and the wide range of phenotypic expression can be explained by the interaction of a number of key genes with environmental factors. Heritability of PCOS has… CONTINUE READING
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Association of the polycystic ovary syndrome with genomic variants related to insulin resistance, type 2 diabetes mellitus, and obesity

  • JL San Millan, M Corton, G Villuendas, J Sancho, B Peral, HF Escobar-Morreale
  • J Clin Endocrinol Metab
  • 2004
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