Polycystic ovary syndrome: evidence for reduced sensitivity of the gonadotropin-releasing hormone pulse generator to inhibition by estradiol and progesterone.

@article{Pastor1998PolycysticOS,
  title={Polycystic ovary syndrome: evidence for reduced sensitivity of the gonadotropin-releasing hormone pulse generator to inhibition by estradiol and progesterone.},
  author={C. Lloret Pastor and M L Griffin-Korf and J A Aloi and William S. Evans and John C. Marshall},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1998},
  volume={83 2},
  pages={582-90}
}
Plasma LH is commonly elevated in women with the polycystic ovary syndrome (PCOS), but the underlying mechanisms are uncertain. We tested the hypothesis that the elevated LH in part reflects a reduced sensitivity of the hypothalamic GnRH pulse generator to suppression by estradiol (E2) and progesterone (P). In an initial protocol, normal controls (beginning on cycle days 8-10) and women with PCOS were given E2 transdermally and P by vaginal suppository (three times daily), to achieve plasma… CONTINUE READING

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