Polycystic ovary syndrome: chemical pharmacotherapy

@article{Rocca2015PolycysticOS,
  title={Polycystic ovary syndrome: chemical pharmacotherapy},
  author={Morena Luigia Rocca and Roberta Venturella and Rita Mocciaro and Annalisa Di Cello and Angela Sacchinelli and Valentina Russo and Simona Trapasso and Fulvio Zullo and Michele Morelli},
  journal={Expert Opinion on Pharmacotherapy},
  year={2015},
  volume={16},
  pages={1369 - 1393}
}
Introduction: Polycystic ovary syndrome (PCOS) is the most common reproductive endocrine disease among women of childbearing age. The clinical features are heterogeneous and vary in intensity. Hirsutism, menstrual disorders and infertility are the most frequent conditions observed; however, long-term complications (dyslipidemia, hypertension, cardiovascular disease, type 2 diabetes mellitus, endometrial cancer) are also often described. Each disorder may be managed by tailored strategies… Expand
Will emerging pharmacotherapies improve the management of polycystic ovarian syndrome?
TLDR
By a critical review of literature, no emerging pharmacotherapies for PCOS have been identified and the aim of the editorial is to report all available evidence about AMH involvement in PCOS therapy and to analyze how its evaluation will improve the management of patients, by allowing an individualized approach. Expand
Chinese Herbal Medicine for the Optimal Management of Polycystic Ovary Syndrome.
TLDR
Current research demonstrates that the compounds isolated from herbs have shown beneficial effects for PCOS and when combined in an herbal formula can target both reproductive and metabolic defects simultaneously. Expand
Quercetin and polycystic ovary syndrome, current evidence and future directions: a systematic review
TLDR
Evidence is provided that quercetin could be considered as a potential agent to attenuate PCOS complications, however, due to the paucity of high-quality clinical trials, further studies are needed. Expand
Oriental herbal medicine and moxibustion for polycystic ovary syndrome
TLDR
According to current evidence, OHM combined with moxibustion might be beneficial for treating PCOS and the treatment might improve the therapeutic effects of conventional WMs including clomiphene citrate, oral contraceptives, and/or metformin. Expand
Natural Approach to Coexisting Non-alcoholic Fatty Liver Disease and Polycystic Ovarian Syndrome
TLDR
Chinese medicine formulae with multiple natural ingredients may have beneficial endocrine, cardio metabolic and reproductive effects offering an optimal treatment approach for women with NAFLD, PCOS and infertility. Expand
Polycystic ovary syndrome management: a review of the possible amazing role of berberine
Purpose The therapy of polycystic ovary syndrome (PCOS) is based on synthetic hormones associated with lifestyle changes, but these therapies cannot be taken continuously, especially by women whoExpand
Polycystic ovary syndrome and risk of endometrial, ovarian, and breast cancer: a systematic review
TLDR
The associations between PCOS and endometrial, ovarian, and breast cancer are complex, with the need to consider many methodological issues in future analyses, and larger well-designed studies, or pooled analyses, may help clarify these complex associations. Expand
Neurokinin B Receptor Antagonism in Women With Polycystic Ovary Syndrome: A Randomized, Placebo-Controlled Trial.
TLDR
The NK3 receptor antagonist AZD4901 specifically reduced LH pulse frequency and subsequently serum LH and T concentrations, thus presentingNK3 receptor antagonism as a potential approach to treating the central neuroendocrine pathophysiology of PCOS. Expand
Effects of moxibustion on reproduction and metabolism of polycystic ovary syndrome: a protocol for meta-analysis and systematic review
TLDR
This study protocol was designed to objectively review and evaluate the effectiveness and safety of moxibustion treatment for PCOS, and primary outcomes will be the ovulation rate, pregnancy rate and sex hormone levels. Expand
Chromium supplementation does not improve weight loss or metabolic and hormonal variables in patients with polycystic ovary syndrome: A systematic review.
TLDR
The articles reviewed demonstrated that chromium supplementation has limited effects on weight reduction, glucose control, lipid profile, and hormonal disturbance of women withPCOS; however, more studies are needed due to the clinical changes observed in patients with PCOS after chromium supplements. Expand
...
1
2
3
4
...

References

SHOWING 1-10 OF 270 REFERENCES
Polycystic ovary syndrome: update on diagnosis and treatment.
TLDR
This review organizes this multi-system approach around the mnemonic "MY PCOS" and discusses evaluation and treatment options for the reproductive, cosmetic, and metabolic complications of this condition. Expand
Diagnosis and Management of Polycystic Ovary Syndrome
TLDR
Women with PCOS require ongoing surveillance to detect impaired glucose tolerance, hyperlipidaemia, endometrial hyperplasia and consequent complications, and any intervention directed at reducing central obesity will not only improve quality of life but also correct hyperinsulinism and improve fertility and lipid and androgen profiles. Expand
Epidemiology, diagnosis, and management of polycystic ovary syndrome
TLDR
Proper diagnosis and management of PCOS is essential to address patient concerns but also to prevent future metabolic, endocrine, psychiatric, and cardiovascular complications. Expand
Lifestyle changes in women with polycystic ovary syndrome.
TLDR
Lifestyle intervention improves body composition, hyperandrogenism (high male hormones and clinical effects) and insulin resistance in women with PCOS, and provided benefits when compared to minimal treatment for secondary reproductive, anthropometric and reproductive outcomes. Expand
Adverse effects of the common treatments for polycystic ovary syndrome: a systematic review and meta-analysis.
TLDR
Drugs commonly used to treat PCOS appear to be associated with very low risk of severe adverse effects although data are extrapolated from other populations. Expand
Aromatase inhibitors for subfertile women with polycystic ovary syndrome.
TLDR
Evaluating the effectiveness and safety of aromatase inhibitors for subfertile women with anovulatory PCOS found letrozole to be at least as effective as the first-line treatment clomiphene citrate and the birth rate was higher in the letroZole group. Expand
Statins for women with polycystic ovary syndrome not actively trying to conceive.
TLDR
There is no evidence that statins improve resumption of menstrual regularity or spontaneous ovulation, nor is there any improvement of hirsutism or acne, and there is a need for further research to be performed with large sample sizes and well-designed RCTs to assess clinical outcomes. Expand
Polycystic ovary syndrome: current and future treatment paradigms.
  • R. Legro
  • Medicine
  • American journal of obstetrics and gynecology
  • 1998
TLDR
Empirical studies of interventions that improve insulin sensitivity in polycystic ovary syndrome (either weight loss and diet programs or pharmaceutical agents) have been shown to improve the endocrine abnormalities in the syndrome. Expand
Nonobese women with polycystic ovary syndrome respond better than obese women to treatment with metformin.
TLDR
The data suggest that nonobese patients respond better than obese patients to a 1.5 g/day metformin regimen, and the mean basal serum total testosterone, free testosterone, and androstenedione concentrations decreased by 38%, 58%, and 30%, respectively. Expand
Therapy in endocrine disease: treatment of hirsutism in the polycystic ovary syndrome.
TLDR
There are different phenotypes of women with hirsutism and PCOS that may require specific attention in the choice of treatment, and when obesity is present, lifestyle intervention should be always considered, and if necessary combined with pharmacotherapy. Expand
...
1
2
3
4
5
...