Polycystic kidney disease-like domains of clostridial collagenases and their role in collagen recruitment.

@article{Eckhard2011PolycysticKD,
  title={Polycystic kidney disease-like domains of clostridial collagenases and their role in collagen recruitment.},
  author={Ulrich Eckhard and Katharina H{\"a}ussermann},
  journal={Biological chemistry},
  year={2011},
  volume={392 11},
  pages={1039-45}
}
Bacterial collagenases exhibit a multimodular domain organization. While the N-terminal collagenase unit harbors the catalytic zinc and suffices to degrade peptidic substrates, collagen substrates come in different types, explaining the requirement for accessory domains such as polycystic kidney disease (PKD)-like domains for efficient catalysis. How the recognition and unfolding of (micro-)fibrillar or triple-helical collagen is accomplished are only poorly understood. Here, we present the… CONTINUE READING

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Role of the N-terminal polycystic kidney disease domain in chitin degradation by chitinase A from a marine Brought to you by | University of Georgia Libraries Authenticated

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