Polycystic kidney disease: FPC in ARPKD

  title={Polycystic kidney disease: FPC in ARPKD},
  author={Susan J. Allison},
  journal={Nature Reviews Nephrology},
Although mutations in PKHD1 are known to cause autosomal recessive polycystic kidney disease (ARPKD), very little is known about the function of its gene product, fibrocystin/ polyductin (FPC). Recent research using a novel mouse model to enable tracking of full-length FPC and its cleaved C-terminus has provided new insights into the processing of FPC and… CONTINUE READING