Polycystic Ovarian Syndrome and Fertility

  title={Polycystic Ovarian Syndrome and Fertility},
  author={Jessica A Lentscher and Breonna Slocum and Saioa Torrealday},
  journal={Clinical Obstetrics and Gynecology},
  pages={65 - 75}
Polycystic ovary syndrome (PCOS) is a common endocrinopathy that has been associated with impaired fertility. This chapter reviews the underlying pathophysiology of PCOS and the associated fertility barriers of the condition. Psychologic concerns, hypothalamic-pituitary, ovarian, and mitochondria dysfunction, obesity, and the role of vitamin D in PCOS are considered with respect to fertility. Lastly, pregnancy risk factors associated with PCOS are also reviewed. 

Therapeutic Effects of Eugenol in Polycystic Ovarian Rats Induced by Estradiol Valerate: A Histopathological and A Biochemical Study

Eugenol showed beneficial effects on serum glucose, serum insulin, fat profile, reproductive hormones, liver activity, oxidative stress, expression of Cox-2 and Ppar-α genes, as well as restoration of normal ovulation in the PCOS animals, which could represent a promising natural product to prevent PCOS or reduce its symptoms.

C850T Polymorphism in Tumor Necrosis Factor Alpha gene in Women with Polycystic Ovarian Syndrome: A Physiological Genetic Validation

  • Omaima Nassir
  • Biology
    Bioscience Biotechnology Research Communications
  • 2021
The CT genotype had higher TNF-α levels than the CC genotype, and the C850T polymorphism was not related with PCOS in women, according to the findings of this study.

Mitofusins: from mitochondria to fertility

The role of Mfns in the regulation of mammalian fertility, including spermatogenesis, oocyte maturation, and embryonic development is highlighted, and the role of certain diseases associated with the reproductive system and their potential as therapeutic targets are highlighted.



Polycystic ovary syndrome and mitochondrial dysfunction

Previous and recent findings concerning the relationship between mitochondrial dysfunction and PCOS are summarized and discussed.

Therapeutic approach for metabolic disorders and infertility in women with PCOS

The use of oral contraceptives has been shown effective in reducing acne and hirsutism and regulates the menstrual cycle, and the addition of antiandrogens to estrogen–progestin therapy has significantly improved the results.

Vitamin D in the aetiology and management of polycystic ovary syndrome

There may be a place for vitamin D supplementation in the management of this syndrome, but current evidence is limited and additional randomized controlled trials are required to confirm the potential benefits of vitamin D supplements in this population.

Pregnancy complications in women with polycystic ovary syndrome.

Pregnant women with PCOS experience a higher incidence of perinatal morbidity from gestational diabetes, pregnancy-induced hypertension, and preeclampsia, and their babies are at an increased risk of neonatal complications, such as preterm birth and admission at a neonatal intensive care unit.

A meta-analysis of pregnancy outcomes in women with polycystic ovary syndrome.

In conclusion, women with PCOS are at increased risk of pregnancy and neonatal complications and pre-pregnancy, antenatal and intrapartum care should be aimed at reducing these risks.

Polycystic ovarian syndrome and the risk of spontaneous abortion following assisted reproductive technology treatment.

The results of this study suggest that the higher risk of spontaneous abortion observed in women with PCOS is likely to be due to their high prevalence of obesity and the type of treatment they receive.

Association between polycystic ovary syndrome and the risk of pregnancy complications

Overall, PCOS in pregnancy was associated with greater risk of GDM, preeclampsia, PIH, preterm delivery, cesarean delivery, miscarriage, hypoglycemia, and perinatal death, and subgroup analysis suggested that these associations might be influenced by study design and pre-BMI.

Obstetric outcome in women with polycystic ovarian syndrome.

It is concluded that PCOS slightly increases the risk for GDM, but does not have an important effect on the rate of premature delivery and pre-eclampsia.