Polycyclic aromatic hydrocarbons suppress meiosis in primordial germ cells via the AHR signaling pathway.

@article{Ge2012PolycyclicAH,
  title={Polycyclic aromatic hydrocarbons suppress meiosis in primordial germ cells via the AHR signaling pathway.},
  author={Chutian Ge and Jian Chun Ye and Qin Wang and Caiqiao Zhang and Jun-Mo Yang and Guoying Qian},
  journal={Toxicology letters},
  year={2012},
  volume={210 3},
  pages={285-92}
}
Numerous studies have demonstrated that polycyclic aromatic hydrocarbon (PAH) exposure during pregnancy is associated with negative reproductive consequences in adulthood, such as reduced sperm production and oocyte destruction in human and laboratory animals. However, the mechanism(s) underlying these epidemiological findings is still unclear, largely due to the lack of an in vitro model of gametogenesis. Here we established an in vitro model of gametogenesis through retinoic acid (RA)-induced… CONTINUE READING
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