Polycyclic aromatic hydrocarbons disrupt axial development in sea urchin embryos through a beta-catenin dependent pathway.

@article{Pillai2003PolycyclicAH,
  title={Polycyclic aromatic hydrocarbons disrupt axial development in sea urchin embryos through a beta-catenin dependent pathway.},
  author={Murali C. Pillai and Carol A. Vines and Athula H. Wikramanayake and Gary N Cherr},
  journal={Toxicology},
  year={2003},
  volume={186 1-2},
  pages={
          93-108
        }
}
Sea urchin (Lytechinus anemesis) embryos were used as an experimental system to investigate the mechanisms of the developmental toxicity of creosote, one of the most widely used wood preserving chemicals, as well as some of its polycyclic aromatic hydrocarbon (PAH) constituents (phenanthrene, fluoranthene, fluorene, pyrene and quinoline). Data suggest that creosote and PAHs affect axial development and patterning in sea urchin embryos by disrupting the regulation of beta-catenin, a crucial… CONTINUE READING
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