Polycyclic aromatic hydrocarbons (PAHs) present in ambient urban dust drive proinflammatory T cell and dendritic cell responses via the aryl hydrocarbon receptor (AHR) in vitro

@inproceedings{ODriscoll2018PolycyclicAH,
  title={Polycyclic aromatic hydrocarbons (PAHs) present in ambient urban dust drive proinflammatory T cell and dendritic cell responses via the aryl hydrocarbon receptor (AHR) in vitro},
  author={Chelsea A. O'Driscoll and Madeline E. Gallo and Erica J Hoffmann and John H Fechner and James J. Schauer and Christopher A. Bradfield and Joshua D Mezrich},
  booktitle={PloS one},
  year={2018}
}
Atmospheric particulate matter (PM) is a complex component of air pollution that is a composed of inorganic and organic constituents. The chemically-extracted organic fraction (OF) of PM excludes inorganics but retains most organic constituents like polycyclic aromatic hydrocarbons (PAHs). PAHs are ubiquitous environmental toxicants and known aryl hydrocarbon receptor (AHR) ligands. The AHR is a ligand activated transcription factor that responds to endogenous ligands and exogenous ligands… CONTINUE READING

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