Polycyclic aromatic hydrocarbon-DNA adducts in spontaneously aborted fetal tissue.

@article{Hatch1990PolycyclicAH,
  title={Polycyclic aromatic hydrocarbon-DNA adducts in spontaneously aborted fetal tissue.},
  author={Maureen C. Hatch and Dorothy Warburton and Regina M. Santella},
  journal={Carcinogenesis},
  year={1990},
  volume={11 9},
  pages={1673-5}
}
Fetal tissue and placentas from 15 human spontaneous abortions were evaluated for DNA adducts of polycyclic aromatic hydrocarbons (PAHs), using a competitive enzyme-linked immunosorbent assay (ELISA) with fluorescent end-point detection. PAH-derived adducts were found in 43% of placentas, 27% of fetal liver samples and 42% of fetal lung specimens, thus confirming that the human fetus is a target for DNA damage. As there was only 60% concordance between placenta and fetal lung or liver on the… CONTINUE READING

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