Polycomb response elements mediate the formation of chromosome higher-order structures in the bithorax complex

@article{Lanzuolo2007PolycombRE,
  title={Polycomb response elements mediate the formation of chromosome higher-order structures in the bithorax complex},
  author={Chiara Lanzuolo and Virginie Roure and Job Dekker and Fr{\'e}d{\'e}ric Bantignies and Valerio Orlando},
  journal={Nature Cell Biology},
  year={2007},
  volume={9},
  pages={1167-1174}
}
In Drosophila, the function of the Polycomb group genes (PcGs) and their target sequences (Polycomb response elements (PREs)) is to convey mitotic heritability of transcription programmes — in particular, gene silencing. As part of the mechanisms involved, PREs are thought to mediate this transcriptional memory function by building up higher-order structures in the nucleus. To address this question, we analysed in vivo the three-dimensional structure of the homeotic locus bithorax complex (BX-C… CONTINUE READING
Highly Influential
This paper has highly influenced 16 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 142 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 36 references

Similar Papers

Loading similar papers…