Polycomb repressor complex 2 regulates HOXA9 and HOXA10, activating ID2 in NK/T-cell lines

@inproceedings{Nagel2009PolycombRC,
  title={Polycomb repressor complex 2 regulates HOXA9 and HOXA10, activating ID2 in NK/T-cell lines},
  author={Stefan Nagel and Letizia Venturini and Victor E. Marquez and Corinna Meyer and Maren E Kaufmann and Michaela E. Scherr and Roderick A F Macleod and Hans Guenter Drexler},
  booktitle={Molecular Cancer},
  year={2009}
}
NK- and T-cells are closely related lymphocytes, originating from the same early progenitor cells during hematopoiesis. In these differentiation processes deregulation of developmental genes may contribute to leukemogenesis. Here, we compared expression profiles of NK- and T-cell lines for identification of aberrantly expressed genes in T-cell acute lymphoblastic leukemia (T-ALL) which physiologically regulate the differentiation program of the NK-cell lineage. This analysis showed high… CONTINUE READING