Polycomb repressive complex 2 is necessary for the normal site-specific O-GlcNAc distribution in mouse embryonic stem cells.

@article{Myers2011PolycombRC,
  title={Polycomb repressive complex 2 is necessary for the normal site-specific O-GlcNAc distribution in mouse embryonic stem cells.},
  author={Samuel A Myers and Barbara Panning and Alma L. Burlingame},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 23},
  pages={9490-5}
}
The monosaccharide addition of an N-acetylglucosamine to serine and threonine residues of nuclear and cytosolic proteins (O-GlcNAc) is a posttranslational modification emerging as a general regulator of many cellular processes, including signal transduction, cell division, and transcription. The sole mouse O-GlcNAc transferase (OGT) is essential for embryonic development. To understand the role of OGT in mouse development better, we mapped sites of O-GlcNAcylation of nuclear proteins in mouse… CONTINUE READING
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