Polycomb proteins targeted by a short repeat RNA to the mouse X chromosome.

@article{Zhao2008PolycombPT,
  title={Polycomb proteins targeted by a short repeat RNA to the mouse X chromosome.},
  author={Jennifer J. Zhao and Bryan K Sun and Jennifer A Erwin and Ji-Joon Song and Jeannie T Lee},
  journal={Science},
  year={2008},
  volume={322 5902},
  pages={
          750-6
        }
}
To equalize X-chromosome dosages between the sexes, the female mammal inactivates one of her two X chromosomes. X-chromosome inactivation (XCI) is initiated by expression of Xist, a 17-kb noncoding RNA (ncRNA) that accumulates on the X in cis. Because interacting factors have not been isolated, the mechanism by which Xist induces silencing remains unknown. We discovered a 1.6-kilobase ncRNA (RepA) within Xist and identified the Polycomb complex, PRC2, as its direct target. PRC2 is initially… CONTINUE READING

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