Polycomb protein Ezh1 promotes RNA polymerase II elongation.

  title={Polycomb protein Ezh1 promotes RNA polymerase II elongation.},
  author={Kambiz Mousavi and Hossein Zare and Aibing Wang and Vittorio Sartorelli},
  journal={Molecular cell},
  volume={45 2},
Polycomb group (PcG) proteins initiate the formation of repressed chromatin domains and regulate developmental gene expression. A mammalian PcG protein, enhancer of zeste homolog 2 (Ezh2), triggers transcriptional repression by catalyzing the addition of methyl groups onto lysine 27 of histone H3 (H3K27me2/3). This action facilitates the binding of other PcG proteins to chromatin for purposes of transcriptional silencing. Interestingly, there exists a paralog of Ezh2, termed Ezh1, whose primary… CONTINUE READING
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