Polycomb-mediated silencing in neuroendocrine prostate cancer

  title={Polycomb-mediated silencing in neuroendocrine prostate cancer},
  author={Pier-Luc Clermont and D T S Lin and Francesco Crea and Rebecca Chung-Fern Wu and Hui Xue and Yuwei Wang and Kelsie L. Thu and Wan L. Lam and Colin Collins and Yuzhuo Wang and Cheryl D. Helgason},
  booktitle={Clinical Epigenetics},
Neuroendocrine prostate cancer (NEPC) is a highly aggressive subtype of prostate cancer (PCa) for which the median survival remains less than a year. Current treatments are only palliative in nature, and the lack of suitable pre-clinical models has hampered previous efforts to develop novel therapeutic strategies. Addressing this need, we have recently established the first in vivo model of complete neuroendocrine transdifferentiation using patient-derived xenografts. Few genetic differences… CONTINUE READING
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how polycomb proteins regulate neurogenesis

  • Testa G. The time of timing
  • Bioessays. 2011;33:519–28. Clermont et al…
  • 2015
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