Polycomb inhibits histone acetylation by CBP by binding directly to its catalytic domain.

Abstract

Drosophila Polycomb (PC), a subunit of Polycomb repressive complex 1 (PRC1), is well known for its role in maintaining repression of the homeotic genes and many others and for its binding to trimethylated histone H3 on Lys 27 (H3K27me3) via its chromodomain. Here, we identify a novel activity of PC: inhibition of the histone acetylation activity of CREB… (More)
DOI: 10.1073/pnas.1515465113

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@article{Tie2016PolycombIH, title={Polycomb inhibits histone acetylation by CBP by binding directly to its catalytic domain.}, author={Feng Tie and Rakhee Banerjee and Chen Fu and Carl A Stratton and Ming Fang and Peter Harte}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={2016}, volume={113 6}, pages={E744-53} }