Polycomb genes, miRNA, and their deregulation in B-cell malignancies.
@article{Wang2015PolycombGM, title={Polycomb genes, miRNA, and their deregulation in B-cell malignancies.}, author={G. Wang and Kyle D. Konze and J. Tao}, journal={Blood}, year={2015}, volume={125 8}, pages={ 1217-25 } }
Posttranslational modifications of histone proteins represent a fundamental means to define distinctive epigenetic states and regulate gene expression during development and differentiation. Aberrations in various chromatin-modulation pathways are commonly used by tumors to initiate and maintain oncogenesis, including lymphomagenesis. Recently, increasing evidence has demonstrated that polycomb group (PcG) proteins, a subset of histone-modifying enzymes known to be crucial for B-cell maturation… Expand
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