Polycomb genes, miRNA, and their deregulation in B-cell malignancies.

@article{Wang2015PolycombGM,
  title={Polycomb genes, miRNA, and their deregulation in B-cell malignancies.},
  author={G. Wang and Kyle D. Konze and J. Tao},
  journal={Blood},
  year={2015},
  volume={125 8},
  pages={
          1217-25
        }
}
Posttranslational modifications of histone proteins represent a fundamental means to define distinctive epigenetic states and regulate gene expression during development and differentiation. Aberrations in various chromatin-modulation pathways are commonly used by tumors to initiate and maintain oncogenesis, including lymphomagenesis. Recently, increasing evidence has demonstrated that polycomb group (PcG) proteins, a subset of histone-modifying enzymes known to be crucial for B-cell maturation… Expand
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References

SHOWING 1-10 OF 111 REFERENCES
Polycomb repressive complex 2 (PRC2) suppresses Eμ-myc lymphoma.
  • 25
Deregulated expression of the polycomb-group protein SUZ12 target genes characterizes mantle cell lymphoma.
  • 43
EZH2-mediated epigenetic silencing in germinal center B cells contributes to proliferation and lymphomagenesis.
  • 240
EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations
  • 1,304
Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation
  • W. Qi, H. Chan, +25 authors E. Li
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 2012
  • 459
  • PDF
The Polycomb group protein Bmi-1 is essential for the growth of multiple myeloma cells.
  • 69
  • PDF
Coordinated regulation of polycomb group complexes through microRNAs in cancer.
  • 194
MYC stimulates EZH2 expression by repression of its negative regulator miR-26a.
  • 376
  • PDF
Role of microRNAs in B cell leukemias and lymphomas.
  • 12
...
1
2
3
4
5
...