Polycomb function during oogenesis is required for mouse embryonic development.

@article{Psfai2012PolycombFD,
  title={Polycomb function during oogenesis is required for mouse embryonic development.},
  author={Eszter P{\'o}sfai and Rico Kunzmann and Vincent Brochard and Juliette Salvaing and Erik Cabuy and Tim C. Roloff and Zichuan Liu and Mathieu Tardat and Maarten van Lohuizen and M D Rubio Vidal and Nathalie Beaujean and Antoine H F M Peters},
  journal={Genes & development},
  year={2012},
  volume={26 9},
  pages={920-32}
}
In mammals, totipotent embryos are formed by fusion of highly differentiated gametes. Acquisition of totipotency concurs with chromatin remodeling of parental genomes, changes in the maternal transcriptome and proteome, and zygotic genome activation (ZGA). The inefficiency of reprogramming somatic nuclei in reproductive cloning suggests that intergenerational inheritance of germline chromatin contributes to developmental proficiency after natural conception. Here we show that Ring1 and Rnf2… CONTINUE READING

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Mentioned Connections BETA
GenomeNo subtypeProteome
Acquisition of totipotency concurs with chromatin remodeling of parental genomes , changes in the maternal transcriptome and proteome , and zygotic genome activation ( ZGA ) .
Acquisition of totipotency concurs with chromatin remodeling of parental genomes , changes in the maternal transcriptome and proteome , and zygotic genome activation ( ZGA ) .
Acquisition of totipotency concurs with chromatin remodeling of parental genomes , changes in the maternal transcriptome and proteome , and zygotic genome activation ( ZGA ) .
ProteomeNo subtypeGenome
Acquisition of totipotency concurs with chromatin remodeling of parental genomes , changes in the maternal transcriptome and proteome , and zygotic genome activation ( ZGA ) .
Polycomb-Group ProteinsGene product plays role in biological processEmbryonic Development
Polycomb function during oogenesis is required for mouse embryonic development .
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