Polycomb-dependent H3K27me1 and H3K27me2 regulate active transcription and enhancer fidelity.

  title={Polycomb-dependent H3K27me1 and H3K27me2 regulate active transcription and enhancer fidelity.},
  author={Karin Johanna Ferrari and Andrea Scelfo and Sriganesh Jammula and Alessandro Cuomo and Iros Barozzi and Alexandra Stuetzer and Wolfgang Fischle and Tiziana Bonaldi and Diego Pasini},
  journal={Molecular cell},
  volume={53 1},
H3K27me3 is deposited at promoters by the preferential association of Polycomb repressive complex 2 (PRC2) with CpG-rich DNA elements regulating development by repressing gene transcription. H3K27 is also present in mono- and dimethylated states; however, the functional roles of H3K27me1 and H3K27me2 deposition remain poorly characterized. Here, we show that PRC2 activity is not only associated with H3K27me3 but also regulates all forms of H3K27 methylation in a spatially defined manner… CONTINUE READING
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