Polycomb chromobox 4 enhances migration and pulmonary metastasis of hepatocellular carcinoma cell line MHCC97L

@article{Mei2014PolycombC4,
  title={Polycomb chromobox 4 enhances migration and pulmonary metastasis of hepatocellular carcinoma cell line MHCC97L},
  author={Zhu Mei and Huike Jiao and Wei Wang and Jie Li and Guoqiang Chen and Ying Xu},
  journal={Science China Life Sciences},
  year={2014},
  volume={57},
  pages={610-617}
}
We recently report that the expression of polycomb chromobox 4 (Cbx4) is significantly correlated with the overall survival of a great cohort of hepatocellular carcinoma (HCC) patients and it enhances hypoxia-induced vascular endothelial growth factor (VEGF) expression and angiogenesis in HCC cells through enhancing sumoylation of hypoxia inducible factor-1alpha (HIF-1α). Here we continue to investigate the potential effects of Cbx4 on the migration and metastasis of the metastatic HCC cell… CONTINUE READING