Polycomb- and REST-associated histone deacetylases are independent pathways toward a mature neuronal phenotype

@inproceedings{McGann2014PolycombAR,
  title={Polycomb- and REST-associated histone deacetylases are independent
pathways toward a mature neuronal phenotype},
  author={James C McGann and Jon A. Oyer and Saurabh Garg and Huilan Yao and Jun Liu and Xin Feng and Lujian Liao and John R. Yates and Gail Mandel},
  booktitle={eLife},
  year={2014}
}
The bivalent hypothesis posits that genes encoding developmental regulators required for early lineage decisions are poised in stem/progenitor cells by the balance between a repressor histone modification (H3K27me3), mediated by the Polycomb Repressor Complex 2 (PRC2), and an activator modification (H3K4me3). In this study, we test whether this mechanism applies equally to genes that are not required until terminal differentiation. We focus on the RE1 Silencing Transcription Factor (REST… CONTINUE READING
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