Polycomb Repressive Complex 1 Generates Discrete Compacted Domains that Change during Differentiation.

Abstract

Master regulatory genes require stable silencing by the polycomb group (PcG) to prevent misexpression during differentiation and development. Some PcG proteins covalently modify histones, which contributes to heritable repression. The role for other effects on chromatin structure is less understood. We characterized the organization of PcG target genes in… (More)
DOI: 10.1016/j.molcel.2017.01.009

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@article{Kundu2017PolycombRC, title={Polycomb Repressive Complex 1 Generates Discrete Compacted Domains that Change during Differentiation.}, author={Sharmistha Kundu and Fei Ji and Hongjae Sunwoo and Gaurav Jain and Jeannie T Lee and Ruslan I Sadreyev and Job Dekker and Robert E. Kingston}, journal={Molecular cell}, year={2017}, volume={65 3}, pages={432-446.e5} }