Polycomb-Dependent Regulatory Contacts between Distant Hox Loci in Drosophila

@article{Bantignies2011PolycombDependentRC,
  title={Polycomb-Dependent Regulatory Contacts between Distant Hox Loci in Drosophila},
  author={Fr{\'e}d{\'e}ric Bantignies and Virginie Roure and Itys Comet and Benjamin J. LeBlanc and Bernd Schuettengruber and Jerome Bonnet and Vanessa Tixier and Andr{\'e} Mas and Giacomo Cavalli},
  journal={Cell},
  year={2011},
  volume={144},
  pages={214-226}
}
In Drosophila melanogaster, Hox genes are organized in an anterior and a posterior cluster, called Antennapedia complex and bithorax complex, located on the same chromosome arm and separated by 10 Mb of DNA. Both clusters are repressed by Polycomb group (PcG) proteins. Here, we show that genes of the two Hox complexes can interact within nuclear PcG bodies in tissues where they are corepressed. This colocalization increases during development and depends on PcG proteins. Hox gene contacts are… CONTINUE READING
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