Polycomb Binding Precedes Early-Life Stress Responsive DNA Methylation at the Avp Enhancer

@inproceedings{Murgatroyd2014PolycombBP,
  title={Polycomb Binding Precedes Early-Life Stress Responsive DNA Methylation at the Avp Enhancer},
  author={Christopher A. Murgatroyd and Dietmar Spengler},
  booktitle={PloS one},
  year={2014}
}
Early-life stress (ELS) in mice causes sustained hypomethylation at the downstream Avp enhancer, subsequent overexpression of hypothalamic Avp and increased stress responsivity. The sequence of events leading to Avp enhancer methylation is presently unknown. Here, we used an embryonic stem cell-derived model of hypothalamic-like differentiation together with in vivo experiments to show that binding of polycomb complexes (PcG) preceded the emergence of ELS-responsive DNA methylation and… CONTINUE READING
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