Polyclonal antibody-based noncompetitive immunoassay for small analytes developed with short peptide loops isolated from phage libraries.

@article{GonzlezTechera2007PolyclonalAN,
  title={Polyclonal antibody-based noncompetitive immunoassay for small analytes developed with short peptide loops isolated from phage libraries.},
  author={Andr{\'e}s Gonz{\'a}lez-Techera and Hee Joo Kim and Shirley J. Gee and Jerold A Last and Bruce D Hammock and Gualberto Gonz{\'a}lez-Sapienza},
  journal={Analytical chemistry},
  year={2007},
  volume={79 23},
  pages={9191-6}
}
To date, there are a few technologies for the development of noncompetitive immunoassays for small molecules, the most common of which relies on the use of anti-immunocomplex antibodies. This approach is laborious, case specific, and relies upon monoclonal antibody technology for its implementation. We recently demonstrated that, in the case of monoclonal antibody-based immunoassays, short peptide loops isolated from phage display libraries can be used as substitutes of the anti-immunocomplex… CONTINUE READING
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