Polyclonal adaptive regulatory CD4 cells that can reverse type I diabetes become oligoclonal long-term protective memory cells.

@article{Godebu2008PolyclonalAR,
  title={Polyclonal adaptive regulatory CD4 cells that can reverse type I diabetes become oligoclonal long-term protective memory cells.},
  author={Elana Godebu and Daphne Summers-Torres and Melissa M. Lin and Bas J. G. Baaten and Linda M Bradley},
  journal={Journal of immunology},
  year={2008},
  volume={181 3},
  pages={
          1798-805
        }
}
Type 1 diabetes is a CD4 cell-dependent disease that results from destruction of insulin-producing beta cells in pancreatic islets. An ideal therapy would reverse diabetes shortly after onset when islet function in not yet fully ablated, and also prevent re-emergence of disease through the generation of memory cells that control the autoimmune response. In this study, we show that adaptive/induced polyclonal regulatory (TR) cells, which contain islet-reactive cells, fulfill these criteria in… CONTINUE READING
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