Polyclonal Ig production after Epstein-Barr virus infection of human lymphocytes in vitro

@article{Rosn1977PolyclonalIP,
  title={Polyclonal Ig production after Epstein-Barr virus infection of human lymphocytes in vitro},
  author={Anders Ros{\'e}n and P{\'e}ter Attila Gergely and Mikael Jondal and George Klein and Sven Britton},
  journal={Nature},
  year={1977},
  volume={267},
  pages={52-54}
}
APART from the specific anti-Epstein-Barr virus (EBV) response in infectious mononucleosis (IM), there is a strong general increase of antibody levels1. The major increase comprises IgM. As EBV has been shown to infect B lymphocytes selectively2 we hypothesised that the virus triggered the infected cells to release immunoglobulin, much like the effect of certain B-cell mitogens3, although the mechanism of activation must be different. It is known that EBV infection in vitro of human blood… CONTINUE READING