Polychlorinated biphenyls and neurodegenerative disease mortality in an occupational cohort.

@article{Steenland2006PolychlorinatedBA,
  title={Polychlorinated biphenyls and neurodegenerative disease mortality in an occupational cohort.},
  author={Kyle N. Steenland and Misty Jena Hein and Rick T Cassinelli and Mary M. Prince and Nancy B Nilsen and Elizabeth A. Whelan and Martha A. Waters and Avima M. Ruder and Teresa M. Schnorr},
  journal={Epidemiology},
  year={2006},
  volume={17 1},
  pages={8-13}
}
BACKGROUND Production of polychlorinated biphenyls (PCBs) ended in the United States in the 1970s, but PCBs persist in the environment and are detectable in the blood of approximately 80% of Americans over age 50. PCBs decrease dopamine levels in rats and monkeys. Loss of dopamine is the hallmark of Parkinson disease, a neurodegenerative disease. There are no epidemiologic studies of PCBs and neurodegenerative disease. METHODS We conducted a retrospective mortality study of 17,321 PCB-exposed… CONTINUE READING