Polychlorinated biphenyls (PCB 101, PCB 153 and PCB 180) alter leptin signaling and lipid metabolism in differentiated 3T3-L1 adipocytes.

@article{Ferrante2014PolychlorinatedB,
  title={Polychlorinated biphenyls (PCB 101, PCB 153 and PCB 180) alter leptin signaling and lipid metabolism in differentiated 3T3-L1 adipocytes.},
  author={Maria Carmela Ferrante and Paola Amero and Anna Santoro and Anna Monnolo and Raffaele Simeoli and Francesca Di Guida and Giuseppina Mattace Raso and Rosaria Meli},
  journal={Toxicology and applied pharmacology},
  year={2014},
  volume={279 3},
  pages={
          401-8
        }
}
Non-dioxin-like polychlorinated biphenyls (NDL-PCBs) are highly lipophilic environmental contaminants that accumulate in lipid-rich tissues, such as adipose tissue. Here, we reported the effects induced by PCBs 101, 153 and 180, three of the six NDL-PCBs defined as indicators, on mature 3T3-L1 adipocytes. We observed an increase in lipid content, in leptin gene expression and a reduction of leptin receptor expression and signaling, when cells were exposed to PCBs, alone or in combination. These… Expand
Polychlorinated Biphenyls (PCB 101, 153, and 180) Impair Murine Macrophage Responsiveness to Lipopolysaccharide: Involvement of NF-κB Pathway
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Polychlorinated Biphenyl Congener 180 (PCB 180) Regulates Mitotic Clonal Expansion and Enhances Adipogenesis through Modulation of C/EBPβ SUMOylation in Preadipocytes.
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TLDR
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TLDR
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