Polychlorinated biphenyl mixtures (Aroclors) inhibit LPS-induced murine splenocyte proliferation in vitro.

@article{Stack1999PolychlorinatedBM,
  title={Polychlorinated biphenyl mixtures (Aroclors) inhibit LPS-induced murine splenocyte proliferation in vitro.},
  author={Allison Stack and Sanja Altman-Hamamdzic and Pamela J. Morris and Steven D. London and Lucille London},
  journal={Toxicology},
  year={1999},
  volume={139 1-2},
  pages={137-54}
}
The immune system is believed to be a sensitive indicator for adverse polychlorinated biphenyl (PCB)-induced health effects. Four commercial PCB mixtures (Aroclors) or six individual PCB congeners were evaluated for their effect on splenocyte viability and lipopolysaccharide (LPS)-induced splenocyte proliferation in vitro in two strains of mice, C57B1/6 (high affinity aromatic hydrocarbon receptor (AhR) complex) and DBA/J (low affinity AhR complex). All four Aroclors, the selected individual… CONTINUE READING
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