Polychlorinated biphenyl-induced VCAM-1 expression is attenuated in aortic endothelial cells isolated from caveolin-1 deficient mice.

@article{Han2010PolychlorinatedBV,
  title={Polychlorinated biphenyl-induced VCAM-1 expression is attenuated in aortic endothelial cells isolated from caveolin-1 deficient mice.},
  author={Sung Gu Han and Sung Yong Eum and Michal Toborek and Eric J. Smart and Bernhard Hennig},
  journal={Toxicology and applied pharmacology},
  year={2010},
  volume={246 1-2},
  pages={74-82}
}
Exposure to environmental contaminants, such as polychlorinated biphenyls (PCBs), is a risk factor for the development of cardiovascular diseases such as atherosclerosis. Vascular cell adhesion molecule-1 (VCAM-1) is a critical mediator for adhesion and uptake of monocytes across the endothelium in the early stages of atherosclerosis development. The upregulation of VCAM-1 by PCBs may be dependent on functional membrane domains called caveolae. Caveolae are particularly abundant in endothelial… CONTINUE READING

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