Polychlorinated Biphenyls and Cancer: An Epidemiological Assessment

@article{Zani2013PolychlorinatedBA,
  title={Polychlorinated Biphenyls and Cancer: An Epidemiological Assessment},
  author={Claudia Zani and Giuseppe Toninelli and Barbara Filisetti and Francesco Donato},
  journal={Journal of Environmental Science and Health, Part C},
  year={2013},
  volume={31},
  pages={144 - 99}
}
Polychlorinated biphenyls (PCBs) are toxic and persistent chemicals produced between 1930s and 1980s primarily for insulating fluids in heavy-duty electrical equipment in power plants, industries, and large buildings. They persist in the environment and accumulate in plants and animals, and have been classified as probable carcinogens to humans. We performed a systematic review and meta-analysis of scientific literature on the relationship between PCB exposure and human cancer. Two cohorts of… 

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References

SHOWING 1-10 OF 161 REFERENCES

Occupational exposure to polychlorinated biphenyls and cancer risk

TLDR
Overall, studies on occupational exposure to PCBs do not show any excess in all cancer mortality, or in mortality for specific cancer sites of interest, and epidemiological studies on workers occupationally exposed toPCBs are reviewed.

Plasma Levels of Polychlorinated Biphenyls, Non-Hodgkin Lymphoma, and Causation

TLDR
The overall results presented here indicate a strong general causal association between NHL and PCB exposure, including an ecologic analysis of NHL incidence and PCB accumulation over time.

Occupational Exposure to Polychlorinated Biphenyls and Risk of Breast Cancer

TLDR
No overall elevation in breast cancer risk is found after occupational exposure to PCBs, however, the exposure-related risk elevations seen among nonwhite workers warrant further investigation, because the usual reproductive risk factors accounted for little of the increased risk.

Environmental exposure to polychlorinated biphenyls (PCBs) and breast cancer: a systematic review of the epidemiological evidence

TLDR
The epidemiological evidence does not support the hypothesis of an association of environmental exposure to PCBs in adulthood in the general population and risk of breast cancer, although uncertainties remain for selected subgroups of women or individual PCB congeners.

Blood levels of organochlorine residues and risk of breast cancer.

TLDR
In this population of New York City women, breast cancer was strongly associated with DDE in serum but not with PCBs, suggesting that environmental chemical contamination with organochlorine residues may be an important etiologic factor in breast cancer.

Cancer mortality among electric utility workers exposed to polychlorinated biphenyls.

TLDR
It is suggested that PCBs cause cancer, with malignant melanoma being of particular concern in this industry, as well as brain cancer among the most highly exposed men.

Plasma concentrations of polychlorinated biphenyls and the risk of breast cancer: a congener-specific analysis.

TLDR
Exposure to dioxin-like PCBs increases breast cancer risk, and the results may be explained by differences between cases and controls regarding metabolic pathways involved in the biotransformation of both mono-ortho PCBs and estrogens.

A cohort study of Swedish capacitor manufacturing workers exposed to polychlorinated biphenyls (PCBs).

TLDR
There was a significantly increased mortality from cardiovascular diseases among those employed for at least five years in high-exposed jobs, with a latency of 20 years and the reason for the excess of cardiovascular deaths in the high-exposure group is not known.

Carcinogenicity of “Non-Dioxinlike” Polychlorinated Biphenyls

TLDR
Results from a chronic carcinogenicity study in rats indicate that not the dose of total PCBs but the total TCDD or toxic equivalents (TEQs) associated with “dioxinlike” (DL) constituents within a technical mixture are mainly if not exclusively responsible for the development of liver neoplasms in female rats.

Residential Exposure to Polychlorinated Biphenyls and Organochlorine Pesticides and Risk of Childhood Leukemia

TLDR
The findings suggest that PCBs, which are considered probable human carcinogens and cause perturbations of the immune system, may represent a previously unrecognized risk factor for childhood leukemia.
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