Polychlorinated Biphenyls 105 and 118 Form Thyroid Hormone Receptor Agonists after Cytochrome P4501A1 Activation in Rat Pituitary GH3 Cells

@inproceedings{Gauger2007PolychlorinatedB1,
  title={Polychlorinated Biphenyls 105 and 118 Form Thyroid Hormone Receptor Agonists after Cytochrome P4501A1 Activation in Rat Pituitary GH3 Cells},
  author={Kelly J. Gauger and Stefanie Giera and David S. Sharlin and Ruby Bansal and Eric A Iannacone and R. Thomas Zoeller},
  booktitle={Environmental health perspectives},
  year={2007}
}
BACKGROUND Polychlorinated biphenyls (PCBs) may interfere with thyroid hormone (TH) signaling by reducing TH levels in blood, by exerting direct effects on TH receptors (TRs), or both. OBJECTIVE Our objective was to identify individual PCBs that directly affect TH signaling by acting on the TR. METHODS We administered a mixture of six PCB congeners based on their ortho substitution pattern, including PCBs 77 and 126 (non-ortho), PCBs 105 and 118 (mono-ortho), and PCBs 138 and 153 (di-ortho… CONTINUE READING
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