Polychlorinated Biphenyls (PCB 101, 153, and 180) Impair Murine Macrophage Responsiveness to Lipopolysaccharide: Involvement of NF-κB Pathway

@article{Santoro2015PolychlorinatedB,
  title={Polychlorinated Biphenyls (PCB 101, 153, and 180) Impair Murine Macrophage Responsiveness to Lipopolysaccharide: Involvement of NF-$\kappa$B Pathway},
  author={Anna Santoro and Maria Carmela Ferrante and Francesca Di Guida and Claudio Pirozzi and Adriano Lama and Raffaele Simeoli and Maria Teresa Clausi and Anna Monnolo and Maria Pina Mollica and Giuseppina Mattace Raso and Rosaria Meli},
  journal={Toxicological Sciences},
  year={2015},
  volume={147},
  pages={255 - 269}
}
Abstract Non-dioxin-like (NDL) polychlorinated biphenyls (PCBs) are persistent organic pollutants, associated with a range of adverse health effects, including interference with the immune system. In this study, we investigate the capability of NDL-PCBs 101, 153, and 180, 3 of the 6 NDL-PCBs defined as indicators, to impair the immune response in lipopolysaccharide (LPS)-activated J774A.1 and primary murine macrophages. Our results clearly demonstrate that the exposure of J774A.1 and primary… Expand
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