Polycefin, a new prototype of a multifunctional nanoconjugate based on poly(beta-L-malic acid) for drug delivery.

@article{Lee2006PolycefinAN,
  title={Polycefin, a new prototype of a multifunctional nanoconjugate based on poly(beta-L-malic acid) for drug delivery.},
  author={Bong-Seop Lee and Manabu Fujita and Natalya M. Khazenzon and Kolja A. Wawrowsky and Sebastian Wachsmann-Hogiu and Daniel L. Farkas and Keith L. Black and Julia Y. Ljubimova and Eggehard Holler},
  journal={Bioconjugate chemistry},
  year={2006},
  volume={17 2},
  pages={
          317-26
        }
}
A new prototype of nanoconjugate, Polycefin, was synthesized for targeted delivery of antisense oligonucleotides and monoclonal antibodies to brain tumors. The macromolecular carrier contains: 1. biodegradable, nonimmunogenic, nontoxic beta-poly(L-malic acid) of microbial origin; 2. Morpholino antisense oligonucleotides targeting laminin alpha4 and beta1 chains of laminin-8, which is specifically overexpressed in glial brain tumors; 3. monoclonal anti-transferrin receptor antibody for specific… 

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