Polycations increase the efficiency of adenovirus-mediated gene transfer to epithelial and endothelial cells in vitro

@article{Arcasoy1997PolycationsIT,
  title={Polycations increase the efficiency of adenovirus-mediated gene transfer to epithelial and endothelial cells in vitro},
  author={SM Arcasoy and J D Latoche and M I Gondor and BR Pitt and JM Pilewski},
  journal={Gene Therapy},
  year={1997},
  volume={4},
  pages={32-38}
}
Recombinant adenoviruses are being developed for gene therapy for cystic fibrosis and other lung diseases, and for prevention and treatment of vascular thrombosis. A major limitation to the clinical utility of adenoviruses is the low efficiency of gene transfer achieved in vivo. In addition, little is known about the initial interactions between adenoviruses and the target cell. To address the hypothesis that the negative charge presented by membrane glycoproteins reduces the efficiency of… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 44 CITATIONS

Production of chimeric adenovirus.

VIEW 1 EXCERPT
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 21 REFERENCES

Integrins 13 Pilewski JM et al . Adenovirus - mediated gene transfer to submu - a v b 3 and a v b 5 promote adenovirus internalization but notcosal glands in vivo using xenografts

TJ Wickham, P Mathias, DA Cheresh, GR Nemerov
  • Am J Physiol
  • 1995

via the pulmonary artery of rats

Y Shimizu, S. Shaw
  • Circul Res
  • 1995

Effect of polycations on permeability of effect on cell susceptibility to in vitro infection with murine C - glomerular epithelial cell monolayers to albumin

J Hesse, P Ebbesen, G Kristensen, M Hammes, A Singh
  • J Lab Clin Med type viruses and polyion effect on some membrane related func -
  • 1994

Effect of polycations on viruses for gene therapy of cystic fibrosis

DP Rich, AJ Hackett, NB Darby
  • Hum Gene Ther
  • 1993

Mucins in the mainstream

K Cornetta, WF Anderson
  • Nature
  • 1993

Similar Papers

Loading similar papers…