Polycations as prostaglandin synthesis inducers. Stimulation of arachidonic acid release and prostaglandin synthesis in cultured fibroblasts by poly(L-lysine) and other synthetic polycations.

@article{Shier1984PolycationsAP,
  title={Polycations as prostaglandin synthesis inducers. Stimulation of arachidonic acid release and prostaglandin synthesis in cultured fibroblasts by poly(L-lysine) and other synthetic polycations.},
  author={W. Shier and D. Dubourdieu and J. Durkin},
  journal={Biochimica et biophysica acta},
  year={1984},
  volume={793 2},
  pages={
          238-50
        }
}
Poly(L-lysine) hydrobromide stimulates arachidonic acid release with concomitant synthesis and release of prostaglandins and lipoxygenase-mediated metabolites (hydroxyeicosatetraenoic acids) in cultures of 3T3 Swiss mouse fibroblasts biosynthetically labeled with [3H]arachidonic acid. The response is rapid, reversible with trypsin and persists for at least 50 min. An evaluation of the calcium dependence of the hydrolytic process was consistent with the rate-limiting step involving a cell… Expand
Effect of polycations on prostaglandin synthesis in cultured glomerular mesangial cells.
  • N. Alavi
  • Chemistry, Medicine
  • Biochimica et biophysica acta
  • 1990
Neutralization of the anionic sites of cultured rat mesangial cells by poly-L-lysine.
Eosinophils, major basic protein, and polycationic peptides augment bovine airway myocyte Ca2+ mobilization.
Studies of renal eicosanoid synthesis in vivo and in vitro.
Physiologic modulation of bronchial epithelial cell barrier function by polycationic exposure.
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