Polycationic lipids inhibit the pro-inflammatory response to LPS.

  title={Polycationic lipids inhibit the pro-inflammatory response to LPS.},
  author={Matilde Le{\'o}n-Ponte and Mark Gajda Kirchhof and Tina Sun and Tracey Stephens and Bhagirath Singh and Shabaz Sandhu and Joaqu{\'i}n Madrenas},
  journal={Immunology letters},
  volume={96 1},
Lipopolysaccharide (LPS) is a major component of the outer membrane of Gram-negative bacteria. As such, it signals monocytes, macrophages and neutrophils to up-regulate phagocytic functions and to release pro-inflammatory cytokines. Despite the established role of CD14 as the main LPS receptor, the precise nature of the LPS signalling complex and its compartmentalization remain unknown. Interactions of LPS with other cell surface molecules such as TLR-4 and MD-2, and its subsequent… CONTINUE READING