Polycationic calix[8]arenes able to recognize and neutralize heparin.

  title={Polycationic calix[8]arenes able to recognize and neutralize heparin.},
  author={Tommaso Mecca and Grazia M L Consoli and Corrada Geraci and Rita La Spina and Francesca Cunsolo},
  journal={Organic & biomolecular chemistry},
  volume={4 20},
A mutual induced fit mechanism is responsible for the exceptional complexation performances exhibited by calix[8]arene polycations towards heparin. The recognition process was studied in comparison with two other heparin antagonists: protamine and polylysine. The arrangement of multiple functional groups on the flexible macrocyclic scaffold of calix[8]arene… CONTINUE READING