Polycationic Coating on Orthopaedic Implants Inhibits Biofilm Formation in an Infected Ovine Tibial Osteotomy Model

Abstract

INTRODUCTION: Implant associated infections contribute to increased patient morbidity and cost. We have previously reported that surface modification with certain hydrophobic polycations, such as N,Ndodecyl,methyl-polyethylenimine, renders implants bactericidal. Adhesion of serum proteins to the implant and low vascularity in the area of trauma create an… (More)

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